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Publications

Discover peer-reviewed publications by therapeutic area.
The information on this page pertains to select publication resources. It is not intended to serve as a comprehensive list of all publications resources.
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Any content about investigational therapeutics or investigational uses of locally approved products does not establish the safety or efficacy of these therapeutics or uses, and there is no guarantee of local regulatory approval.
The provision of this content is not intended to recommend or suggest use of its products in any manner inconsistent with local regulatory approval. For questions beyond a product’s authorized indications or for information not available here, please contact Alnylam Medical Information.

Publications

Acute Hepatic Porphyria (AHP)

EXPLORE: A Prospective, Multinational, Natural History Study of Patients with Acute Hepatic Porphyria with Recurrent Attacks

Hepatology

Author(s)

Laurent Gouya, Paolo Ventura, Manisha Balwani, et al

Transthyretin Amyloidosis (ATTR)

Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure-Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin-Mediated (hATTR) Amyloidosis

Journal of Clinical Pharmacology

Author(s)

Xiaoping Zhang, Varun Goel, Husain Attarwala, et al

Cardiovascular (CV)

Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen

Hypertension

Author(s)

Estrellita Uijl, Katrina Mirabito Colafella, Yuan Sun, et al

Transthyretin Amyloidosis (ATTR)

Association of Patisiran, an RNA Interference Therapeutic, With Regional Left Ventricular Myocardial Strain in Hereditary Transthyretin Amyloidosis: The APOLLO Study

JAMA Cardiology

Author(s)

Masatoshi Minamisawa, Brian Claggett, David Adams, et al

Acute Hepatic Porphyria (AHP)

Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria

New England Journal of Medicine

Author(s)

Eliane Sardh, Pauline Harper, Manisha Balwani, et al

Transthyretin Amyloidosis (ATTR)

Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis

Circulation

Author(s)

Scott Solomon, David Adams, Arnt Kristen, et al

Acute Hepatic Porphyria (AHP)

Patient Perspective on Acute Intermittent Porphyria with Frequent Attacks: A Disease with Intermittent and Chronic Manifestations

The Patient: Patient-Centered Outcomes Research

Author(s)

Amy Simon, Farrah Pompilus, William Querbes, et al

Transthyretin Amyloidosis (ATTR)

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

New England Journal of Medicine

Author(s)

David Adams, Alejandra Gonzalez-Duarte, William O’Riordan, et al