Therapeutic Areas

Acute Hepatic Porphyria (AHP)
Acute Hepatic Porphyria (AHP)
Transthyretin (ATTR) Amyloidosis
Transthyretin Amyloidosis (ATTR)
Primary Hyperoxaluria Type 1 (PH1)
Primary Hyperoxaluria Type 1 (PH1)
Neurologic
Neurologic
Cardiovascular (CV)
Cardiovascular (CV)

 Science of RNAi

RNAi Mechanism of Action RNAi Mechanism of Action

Image
Video Icon

Video

RNAi Mechanism of Action

This video highlights the mechanism of action (MOA) of RNAi therapeutics and its role in silencing gene expression. This video is intended to be viewed in its entirety.

View more on Alnylam & RNAi Science 

Congresses

Glasgow-uk-mobile

Primary Hyperoxaluria Type 1 (PH1)

European Renal Association (ERA) 2026

Glasgow-uk-mobile
Gdansk-Poland-Mobile

Publications

Transthyretin Amyloidosis (ATTR)

Vutrisiran-Mediated Knockdown of Transthyretin in Patients with ATTR Amyloidosis

Clinical Pharmacokinetics

Author(s)

Marianna Fontana, Vincent Algalarrondo, Pablo Garcia-Pavia, et al

Transthyretin Amyloidosis (ATTR)

Vutrisiran in East Asian Patients With Transthyretin Amyloidosis With Cardiomyopathy: Post-Hoc Analysis of HELIOS-B

JACC: Asia

Author(s)

Jin Endo, Tetsuo Minamino, Jaewon Oh, et al

Transthyretin Amyloidosis (ATTR)

Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy and Renal Impairment: Analyses From HELIOS-B

Journal of Cardiac Failure

Author(s)

Farooq H. Sheikh, Julien Dang, Marianna Fontana, et al

 Connect with Alnylam Medical

For further information or questions related to Alnylam's clinical data, connect with Alnylam Medical.

Image
Medical Information

Medical Information

For Medical Information inquiries, please submit your question using the email below.

For country-specific Medical Information contact details, please navigate to the individual country sites located at Alnylam.com.

Image
Adverse Events/Therapy Complaints

Adverse Events/Product Complaints

To report an adverse event or to submit a product complaint, please use the email below.

For country-specific contact details, please navigate to the individual country sites located at Alnylam.com.

Image
Clinical Trials

Clinical Trials

For clinical trial inquiries, please use the contact options below.